Addictive properties of drug abuse may hold key to an HIV cure

Public release date: 21-Sep-2012
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Contact: Tom Butler
tbutler@admin.fsu.edu
850-644-8634
Florida State University

TALLAHASSEE, Fla. A Florida State University researcher is on a mission to explore the gene-controlling effects of addictive drugs in pursuit of new HIV treatments.

Working under the support of a $1.8 million grant from the National Institutes of Health (NIH), Florida State biologist Jonathan Dennis is studying a unique ability shared between a promising class of HIV treatments known as histone deacetylase inhibitors (HDIs) and psychostimulant drugs such as cocaine.

"Current HIV treatments do just that they treat the disease by preventing the spread of HIV in the body, rather than eliminating the disease entirely," Dennis said. "I want to find out how to root out those dormant HIV cells that are evading the treatment, and I believe the gene-controlling functions shared by HDIs and psychostimulant drugs hold the key to helping us do that."

HDI and addictive drugs such as cocaine share the ability to control gene expression through changes in the chromatin structure within DNA. In the case of HDI treatment, the chromatin changes are used to wake up dormant HIV virus cells that are hiding in the body.

Dennis believes that addictive drugs do the same thing. Dennis' work will focus on identifying and understanding the overlapping gene changes that occur between these two types of substances, ultimately providing other researchers with the foundational information they need to turn HDI treatments into HIV cures.

To learn more about the scope and purpose of Dennis' NIH grant, visit the grant website. To learn more about Dennis, visit his Department of Biological Science website.

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Florida State University, rated RU/VH ("Research University/Very High" research activity) by the Carnegie Foundation for the Advancement of Teaching, is one of the nation's leading research and creative-activity institutions. With nearly $204 million in external research funding in 2011 and a large collection of unique, cutting-edge scientific and performing arts facilities, Florida State offers faculty and students unparalleled opportunities to expand the frontiers of knowledge and discovery in their areas of expertise. To learn more about Florida State research, locate a subject matter expert or arrange an interview on a specific research or creative topic, contact Tom Butler at tbutler@admin.fsu.edu, or Florida State's News and Research Communications Office at (850) 644-4030.

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Public release date: 21-Sep-2012
[ | E-mail | Share ]

Contact: Tom Butler
tbutler@admin.fsu.edu
850-644-8634
Florida State University

TALLAHASSEE, Fla. A Florida State University researcher is on a mission to explore the gene-controlling effects of addictive drugs in pursuit of new HIV treatments.

Working under the support of a $1.8 million grant from the National Institutes of Health (NIH), Florida State biologist Jonathan Dennis is studying a unique ability shared between a promising class of HIV treatments known as histone deacetylase inhibitors (HDIs) and psychostimulant drugs such as cocaine.

"Current HIV treatments do just that they treat the disease by preventing the spread of HIV in the body, rather than eliminating the disease entirely," Dennis said. "I want to find out how to root out those dormant HIV cells that are evading the treatment, and I believe the gene-controlling functions shared by HDIs and psychostimulant drugs hold the key to helping us do that."

HDI and addictive drugs such as cocaine share the ability to control gene expression through changes in the chromatin structure within DNA. In the case of HDI treatment, the chromatin changes are used to wake up dormant HIV virus cells that are hiding in the body.

Dennis believes that addictive drugs do the same thing. Dennis' work will focus on identifying and understanding the overlapping gene changes that occur between these two types of substances, ultimately providing other researchers with the foundational information they need to turn HDI treatments into HIV cures.

To learn more about the scope and purpose of Dennis' NIH grant, visit the grant website. To learn more about Dennis, visit his Department of Biological Science website.

###

Florida State University, rated RU/VH ("Research University/Very High" research activity) by the Carnegie Foundation for the Advancement of Teaching, is one of the nation's leading research and creative-activity institutions. With nearly $204 million in external research funding in 2011 and a large collection of unique, cutting-edge scientific and performing arts facilities, Florida State offers faculty and students unparalleled opportunities to expand the frontiers of knowledge and discovery in their areas of expertise. To learn more about Florida State research, locate a subject matter expert or arrange an interview on a specific research or creative topic, contact Tom Butler at tbutler@admin.fsu.edu, or Florida State's News and Research Communications Office at (850) 644-4030.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-09/fsu-apo092112.php

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